_______ what his parents think, he is leaving home for a new job in a big city.
A. Regardless of B. Instead of
C. In terms of D. Lack of
_______ what his parents think, he is leaving home for a new job in a big city.
A. Regardless of B. Instead of
C. In terms of D. Lack of
解析：选A。句意：不管他父母怎么想的，他还是要离开家，去一所大城市找份新工作。regardless of不管，不顾；instead of代替；in terms of鉴于；lack of缺乏。