the fact that there was thick fog,he drove his car out.
A.Despite B.In spite
C.Although D.No matter how
the fact that there was thick fog,he drove his car out.
A.Despite B.In spite
C.Although D.No matter how
A
表示“尽管，虽然”，通常用although/though引导让步状语从句，而in spite of/despite后通常接名词、代词或动名词，不接句子。本题中the fact是名词，故用despite。B项in spite后缺少of，也可排除。